Ever since the Human Genome Project decoded the genome, the prevailing scientific view has been that only the 2 percent that makes proteins — the building blocks of cells — was important. The rest was deemed not functional, or “junk.” But from his days in graduate school, through his postdoctoral fellowship, and now as a Harvard Stem Cell scientist, John Rinn has been digging through the genome, challenging that prevailing belief.Now, Rinn and his Harvard Stem Cell Institute colleagues, including neurobiologist Paola Arlotta, have carried out an elegant and important experiment in which they have demonstrated that much of what had been dismissed in fact plays as vital a role as protein-coding genes.Rinn and his colleagues have generated 18 strains of mutant mice, removing from each a different piece of “junk” genome, or so-called long intergenic noncoding RNAs (lincRNAs). If the lincRNA truly had been “junk,” nothing should have happened.What the researchers found was the opposite. Obvious defects were observed in seven of the 18 mutant strains. Three died shortly after birth, and there is reason to believe many others also are defective. The authors reported these and more findings in the new online journal eLife, initiated by the Howard Hughes Medical Institute, the Wellcome Trust, and the Max Planck Institute.Martin Sauvageau, Loyal Goff, and Simona Lodato, the lead authors on the study, say it will take years to study all the mice, but an initial global characterization determined that seven had obvious defects, including early death, inadequate size, and lung and brain defects. Others had problems that were more subtle.“There has been a lot of skepticism whether these long noncoding RNAs are important for living organisms,” said Rinn, “but you can’t say this is junk without testing it. The question will always be what percentage is junk, and what’s functional. But what we need to do is look at lincRNAs with the same careful focus we’ve applied to protein-coding genes, using genetics to characterize them, and see what role they play on a molecular and organismal scale.”Rinn and Arlotta see their collaboration as unusual and yet indicative of how the Department of Stem Cell and Regenerative Biology, in which they are both faculty members, brings together scientists of disparate backgrounds and interests.“How do a neuroscientist and an RNA biologist come together?” Rinn asked rhetorically. “That’s the story of our department: two scientists coming together to do something neither would have done on their own. And our labs have become seamless. That’s something the department aims for.“I’m a geneticist who had never worked with mice. Paola is a neuroscientist who had experience with mice, but for whom this kind of genetic experiment was new. But she has a history of being a classic neurobiologist who takes risky, successful technological leaps. This set of experiments constituted a huge risk for both of us, and for the postdocs who did the work,” Rinn said.“We got into this because we thought these [lincRNA] molecules could be another layer of explanation of how a tissue as complex and mysterious as the brain is made,” said Arlotta. “And indeed we found that these are key molecules for brain development.”The lincRNAs control the stem cells that give rise to a “particular class of neurons … that are important in the expansion of the brain, in the part that controls intelligent behavior, cognition and perception, the part of the brain that makes us,” Arlotta said.“When we removed the specific lincRNA, we looked at the mouse brain and the progenitors were reduced. As a consequence probably, the population [of neurons] that sits on top of the cerebral cortex are reduced … It’s likely that in the future we’ll see a number of studies showing that other lincRNAs are involved in specific behaviors,” Arlotta said. “The brain likes this junk RNA.”
Show Closed This production ended its run on Jan. 4, 2015 In addition to Faure, Cinderella currently features Fran Drescher as Madame, Joe Carroll as Prince Topher, Tony winner Victoria Clark as Marie, Ann Harada as Charlotte, Stephanie Gibson as Gabrielle, Todd Buonopane as Jean-Michel, Peter Bartlett as Sebastian and Phumzile Sojola as Lord Pinkleton. As prevoiusly announced, Nancy Opel will assume the role of Madame beginning June 30. Cinderella Related Shows View Comments The shoe fits! Former Cinderella ensemble member Paige Faure will become a leading lady with the help of a little magic beginning June 13. She steps in for “Call Me Maybe” singer Carly Rae Jepsen, who played her final performance on June 8. In addition to Cinderella, Faure has appeared on Broadway in Bullets Over Broadway and How to Succeed in Business Without Really Trying. Other stage credits include A Chorus Line, Chitty Chitty Bang Bang, Little Women and Aida. She will also lead the national tour of Cinderella when it launches in October. Directed by Mark Brokaw, the production brings to the Broadway stage for the first time the tuner that originally aired as a TV special in 1957, starring Oscar winner Julie Andrews. This Cinderella features a completely re-imagined book by Douglas Carter Beane and additional Rodgers and Hammerstein songs originally composed for other musicals.
Beats Antique – OvertureAndy Statman – The French PressBlood Washed Band – Driftin’ AlongBuffalo Clover – TruthfullnessGreg Trooper – The Land of No ForgivenessIf Birds Could Fly – Lonely TownJared Bartman – Garden GateJesse Cobb – SolitudeJesse Terry – Feel That Way AgainJonathan Warren & The Billy Goats – GreyhoundJulie Lee – Too Far GoneKeller Williams & More Than A Little – Let’s JamLe Trouble – Mission BellMiss Tess & The Talk Backs – Sorry You’re SickScott Law – Five PinesScott Miller – Freight Train Heart: Stonewall LoveSmokeStack & The Foothill Fury – Conquer the World With YouSteve Poltz – Song for HawkThe Deep Dark Woods – 18th of DecemberTodd Grebe & Cold Country – Nothing Left To LoseTrampled By Turtles – Codeine In November, we give thanks for many things. Family and friends. Mountain views and pristine waterfalls. A river to paddle and a trail to ride. Turkey and dressing and college football.And music. We give thanks for music. Specifically, right here on Trail Mix, as we are back at it with another fantastic collection of tunes.This month, we kick things off a little differently. While we strive for diversity on Trail Mix, we are best known for featuring top notch Americana. We typically kick each month with something in the bluegrass, folk rock, or alt-country vein. This month, though, we have taken a bit of an electronic detour. Beats Antique have long been known for their trippy, energetic live shows. This Northern California-based trio draws on a wide range of influences – gypsy jazz, afrobeat, and flamenco, to name a few – to create their own blend of electronic folk. We lead November off with “Overture,” from A Thousand Faces: Act 1, the first half of a two disc rock opera project. These guys are a welcome diversion from our typical rootsy fare.Jesse Cobb, former mandolin player for The Infamous Stringdusters, is poised to release his first solo record this month and we are happy to have “Solitude” included in this month’s mix. Be sure to check out “Lonely Town,” from If Birds Could Fly, who hail from Virginia’s coal country. Is Brittany Carter the next great female Americana voice? Could be, and if pans out that way, we’d like you to say that you heard of her here first!November also features some of our tried and true favorite artists. Check out brand new tunes from Keller Williams, Scott Miller, Scott Law, Trampled By Turtles, Julie Lee, Todd Grebe & Cold Country, and The Deep Dark Woods.Of course, we aren’t done yet. There is still plenty more free music to check out. Lately, we have been burning up the new Jesse Terry disc. Check out “Feel That Way Again” and stay tuned for a blog entry later this month. As always, share and stream. Bring Trail Mix with you on your next outdoor adventure. Play these tunes while you cooking for your Thanksgiving shindig. And remember to get out and buy some of these records. These artists will certainly give their thanks to you.
Read Lockn’ Music Festival’s announcement below for more information on the Line-up and event! LOCKN’ Announces 2019 Lineup The LOCKN’ 2019 lineup is announced! Each LOCKN’s has paired artists together to present once-in-a-lifetime collaborations that have become the trademark of the festival. The vibe is made magical by these unique combinations. This year will be no different with collaborations that include Trey Anastasio Band featuring Derek Trucks, Tedeschi Trucks Band featuring Trey Anastasio, and Bob Weir and Wolf Bros featuring Susan Tedeschi, as well as Oteil & Friends with Bob Weir featuring Devon Allman, Duane Betts, and more. This Monday, February 25th, Blue Ridge Outdoors is launching the annual TOP ADVENTURE COLLEGE CONTEST. Thanks to this year sponsor, Lockn’, the prizes for the Top Adventure Colleges are *drum roll* FREE VIP tickets to Lockn’ Music Festival. Click here to vote and to enter to win free tickets. Nice Price Tickets are on now! There’s perhaps no festival anywhere on this globe that captures the vibe of LOCKN’. Make sure you’re there when it happens! Anticipate captivating live music experiences of all kinds with Joe Russo’s Almost Dead, The Revivalists, Jason Isbell, Gary Clark Jr., moe., Twiddle, Pigeons Playing Ping Pong, Preservation Hall Jazz Band, and many more. We can’t wait to be dancing in Garcia’s Forest with early and late shows featuring artists like Fruition, The Lil Smokies, Galactic, and Soulive, letting our inhibitions run wild.The energy and smiling faces inspire LOCKN’ to shine, which is why LOCKN’ been dreaming all year of creating unique journeys to surprise you with. No matter which path you take to LOCKN’, your adventure is right around the corner. VIP Ticket Giveaway
Sign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Nassau County police are warning the public about a suspicious man who tried to lure children into his truck five times over the past four weeks, twice by offering them candy.The children were all between the ages of eight and 16, three of whom were walking either to or from school at the time. Investigators described the suspect as a black man, 20 to 30 years old, driving either a van or an SUV that may have a dented right read door and tinted windows, authorities said.“If a stranger stops their car and asks the child questions, run the opposite direction and tell authorities,” police said in an advisory. “Always walk in groups and stay close to the curb, away from shrubbery and doorways. Do not take shortcuts through alleys, vacant lots or parks.”Police said the confrontations occurred at 4:30 p.m. Monday, April 13 on Melvin Avenue Lakeview, at 7:40 a.m. Wednesday, April 22 at the corner of Woodfield Road and Janos Lane Lakeview, at 2:35 p.m. Thursday, April 23 on Lakeview Avenue in Lynbrook, at 7:45 a.m. Tuesday, May 5 at the corner of Grove Street and Jamaica Avenue in Valley Stream and at 7:30 a.m. Thursday, May 7 at the corner of Orlando Avenue and Champlain Avenue in Lakeview.Detectives ask anyone who spots the suspect to call 911 and anyone with information regarding any of these incidents to call Nassau County Crime Stoppers at 1-800-244-TIPS. All callers will remain anonymous.
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Comment Advertisement Advertisement Jose Mourinho has been impressed with the young defender (Picture: Getty)Jose Mourinho showered Saliba with praise last week amid rumours that his former club, United, were interested in the France Under-19 international.‘I think he has everything needed to become a good player, much like Kurt Zouma, who I signed,’ Mourinho said.More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesSaliba signed a long-term contract with Saint-Etienne last month, with the Ligue 1 outfit anticipating offers for the youngster this summer.Speaking about his contract extension, Saliba said: ‘I am very happy to extend my adventure with Saint-Etienne, the club where I came up from as a youngster.‘I want to thank all my youth coaches and everyone who has contributed to my progression at this club.’MORE: Zinedine Zidane aims swipe at Gareth Bale after denying him Real Madrid farewell Arsenal and Manchester United are both interested in signing William Saliba (left) (Picture: Getty)Arsenal are reportedly preparing to do battle with Manchester United for Saint-Etienne star William Saliba in the summer transfer window.Saliba, 18, has had an outstanding debut season in France, making 17 appearances since breaking into Jean-Louis Gasset’s first-team, and the defender’s accomplished performances have caught the attention of the Premier League’s elite.United have been credited with a strong interest in Saliba and, according to Goal, Arsenal have been keeping close tabs on the teenage centre-back all season.The report claims that Arsenal are convinced by Saliba’s potential and have been impressed with the level of his maturity for such a young player.AdvertisementAdvertisementADVERTISEMENTMore: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityUnai Emery will have just £40 million to spend on reinforcements this summer if the Gunners fail to qualify for the Champions League by beating Chelsea in the Europa League final.The Spaniard will prioritise signing a top-class central defender and Saliba has emerged as the club’s top target in this position. Metro Sport ReporterSunday 19 May 2019 5:42 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link3.5kShares Arsenal lining up transfer move for Manchester United target William Saliba
Saab has secured an order for deliveries of the Sabertooth autonomous underwater vehicle/remotely operated vehicle (AUV/ROV) to an unnamed client. Deliveries will take place during 2018, the company informed.With this contract, the customer has ordered the first vehicles in a planned fleet of Sabertooth vehicles.Under the agreement, Saab and the customer will work together to further develop the vehicle and its applications in the field of subsea inspection, maintenance and repair (IMR), survey and intervention work.“We are pleased to have received this order for an initial number of systems. We will work closely together with the customer as they implement the system and we look forward to supporting them with their strategic focus and continued growth,” said Görgen Johansson, head of Saab’s business area Dynamics.The contract comprises a suite of advanced survey sensors. The Sabertooth system has been configured to allow additional sensors, which can be quickly integrated to meet project specific applications.
RelatedPosts Joe Aribo vows to bounce back from injury Joe Aribo out of Super Eagles friendlies Global COVID-19 cases surpass 27m – Johns Hopkins Rangers midfielder, Joe Aribo, could miss the club’s next “few games” after suffering a head injury in Wednesday’s League Cup win over Livingston.The Nigeria international required 20 stitches after a challenge by Livingston’s Rickie Lamie.Steven Gerrard confirmed Aribo will miss Saturday’s visit of Aberdeen after being “cut all the way to the bone”.“I will be very surprised if we see Aribo play before the international break,” the Rangers boss said.“It is his first time out of London and he has settled very well. This will be a setback but knowing him he will bounce back, he didn’t even want to come off yesterday which shows his mentality.”As well as Aberdeen, Rangers face Young Boys away in the Europa League on Thursday and then Hamilton at Ibrox before the next international break.He also now looks set to miss out on playing for Nigeria against Brazil in Singapore on 13 October, having recently won his first cap.Aribo was substituted before the break in the 1-0 win at the Tony Macaroni Arena after Lamie’s forearm hit the former Charlton midfielder on the head.After the match Gerrard questioned whether the Livingston defender should have remained on the pitch, and repeated his thoughts on Thursday.“I don’t think the player has gone in to intentionally hurt him but that in my book is serious dangerous play and in any other league it is a red card,” he said.Tags: BrazilJoe AriboRangers
Press Association Patchell’s razor sharp right boot gave the visitors a 6-0 lead inside the opening seven minutes, as he punished an initial scrum infringement from Leinster and then fired over from inside his own half. Isa Nacewa hit a post with his first place-kick, but he was then on target – pushing past the 400-point mark for Leinster in the process – following a determined kick chase from Noel Reid and Dominic Ryan. Ben Te’o carried with increasing intent during a fast-paced first quarter, with the home side’s pressure leading to number eight Conan burrowing over under Manoa Vosawai’s challenge from a couple of metres out. TMO Seamus Flannery confirmed the grounding and Nacewa converted from the right. However, despite dominating possession, Leinster were only one point clear at the break. Their full-back and stand-in captain sent a penalty narrowly wide before Patchell made it three from three, this time from halfway. Vosawai’s departure at the interval saw Ellis Jenkins brought on and Blues skipper Josh Navidi move to number eight and with the Welsh outfit still struggling for continuity, a central penalty from Nacewa made it 13-9. Cardiff’s doggedness in defence and ability to win turnovers – as seen with a textbook ruck penalty won by youngster Jenkins in his 22 – launched them forward again and Patchell took full advantage with penalties after 51 and 56 minutes. A powerful Leinster scrum, with replacement prop Royce Burke-Flynn making his presence felt, allowed Nacewa to boot the province back in front with 14 minutes remaining. That set up a grandstand finish with Jenkins doing really well to hold up Bryan Byrne from an advancing Leinster maul. However, a series of scrums and lineouts near the Cardiff line saw Cullen’s charges go for the jugular, particularly after Navidi saw yellow for a maul infringement. Their persistence paid off when Cardiff gave way at a five-metre scrum and referee Ben Whitehouse signalled for a penalty try which Nacewa converted. The Blues should have taken something from the game, but Patchell’s long range drop goal attempt drifted wide in the final seconds. Leinster picked up their first Guinness PRO12 win under new head coach Leo Cullen as they overcame a battling Cardiff Blues side 23-15 at the the RDS. Jack Conan’s 16th-minute try from close range had Cullen’s youthful team leading 10-9 at half-time, with Cardiff fly-half Rhys Patchell booting three penalty goals – two of them from distance. Patchell’s accuracy from the tee had the Blues 15-13 ahead entering the final quarter, but the Leinster forwards, including man-of-the-match Josh van der Flier, dictated play late on and they were rewarded with a clinching penalty try, four minutes from the end.