Nanoscavengers could protect people from sarin gas other nerve agents

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Required fields are indicated by an asterisk (*) By Emily MullinJan. 2, 2019 , 2:00 PM Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Hazardous material specialists rescue a doll during a simulated nerve gas attack in San Diego, California. ‘Nanoscavengers’ could protect people from sarin gas, other nerve agents Sign up for our daily newsletter Get more great content like this delivered right to you! Countrycenter_img Robert Gauthier/Los Angeles Times/Getty Images In the 1980s, thousands of Iranians were killed from exposure to the nerve agents sarin and tobin unleased by Iraqi forces. Similar chemicals have been used against soldiers and civilians in recent wars and terrorist attacks. Now, researchers are reporting a new therapy that may be able to provide long-acting protection against these agents. Though the treatment has only been tested in rodents, some scientists say it could one day prevent lasting brain damage or death in people exposed to these deadly chemical weapons.Nerve agents like sarin belong to a family of chemicals called organophosphates. Although some of these compounds are widely used in much lower concentrations as pesticides, the nerve agents are highly lethal because they get into the body quickly through the respiratory tract, eyes, or skin. Once inside cells, they inhibit an important enzyme whose normal function is to break down acetylcholine, a neurotransmitter that helps muscles contract. When too much acetylcholine builds up, victims experience violent muscle spasms and eventually stop breathing.Current antidotes must be given as soon as possible, and although they can help mitigate the symptoms of poisoning, they don’t act directly on nerve agents. As a result, researchers have been trying to develop prophylactic “scavenging” molecules capable of seeking out and degrading nerve agents in the body upon exposure. But such “bioscavengers” have only been able to provide brief protection in various lab animals, and no such therapies have been approved by the U.S. Food and Drug Administration. Email In the current study, researchers at the University of Washington in Seattle tried a new tack. They wrapped an organophosphate-targeting enzyme called OPH in a flexible polymer gel coating. The end result was nanometer-size particles capable of going undetected by the immune system and staying in the body longer than the enzyme alone. When given before exposure to nerve agents, the nanoparticles clear the chemicals from the bloodstream.Rats given a single injection of the “nanoscavenger” were completely protected against organophosphate exposure for up to 5 days without side effects. In treated guinea pigs, the nanoscavenger protected animals from multiple sarin injections for 8 days, the team reports today in Science Translational Medicine.The nanoscavenger could essentially act as a vaccine in people, says chemical engineer Shaoyi Jiang, a member of the team. If the therapy is optimized, the protection could potentially last for weeks or even months, he says.Previous bioscavengers haven’t remained in the body long enough to confer protection, or they’ve sparked the body’s immune system to neutralize the antidote with antibodies, notes Jin Montclare, a protein engineer at New York University in New York City, who was not involved with the study. The new work appears to circumvent both of these concerns, she says.Nerve agent nanoscavengers would be most practical for people who are at high risk of exposure to the chemical weapons, such as soldiers or first responders going into a contaminated area, says Janice Chambers, a toxicologist at Mississippi State University in Starkville who wasn’t involved in the work. But she says the therapy probably wouldn’t be useful for short-notice assaults such as terrorist attacks. “By the time you would be exposed and showing the signs of tremors or convulsions, it would be too late” to give the treatment.The authors say the treatment could also help protect people working with certain pesticides. According to the World Health Organization, pesticides containing organophosphates cause 200,000 poisoning deaths per year in developing countries.Next, the researchers plan to test how long the nanoscavenger works in monkeys, and they will also see whether multiple doses can be given. After that, a clinical trial would be needed to test the safety of the therapy in humans.last_img read more

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